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Find cheap flights from John Wayne (Santa Ana) to South America from $181

This is the cheapest one-way flight price found by a KAYAK user in the last 72 hours by searching for a flight from Santa Ana to South America departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
1 adult
0 bags
qua 7/10
qua 7/17

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Best South America Flight Deals

Cheapest round-trip prices found by our users on KAYAK in the last 72 hours

Lima
Lima2 stops$624
Bogotá
Bogotá1 stop$493
Cartagena
Cartagena1 stop$507
Santiago
Santiago1 stop$711
Quito
Quito2 stops$486
Cali
Cali1 stop$723
Cusco
Cusco2 stops$997
Barranquilla
Barranquilla1 stop$673

Good to know

Low season

November

High season

February

Cheapest flight

$181
Best time to beat the crowds with an average 19% drop in price.
Most popular time to fly and prices are also 7% lower on average.
Flight from Santa Ana to Bogotá

FAQs - booking South America flights

  • How does KAYAK find such low prices on flights from John Wayne (Santa Ana) to South America?

    KAYAK is a travel search engine. That means we look across the web to find the best prices we can find for our users. With over 2 billion flight queries processed yearly, we are able to display a variety of prices and options on flights from John Wayne (Santa Ana) to South America.

  • How does KAYAK's flight Price Forecast tool help me choose the right time to buy my flight ticket from John Wayne (Santa Ana) to South America?

    KAYAK’s flight Price Forecast tool uses historical data to determine whether the price for a flight to South America from John Wayne (Santa Ana) is likely to change within 7 days, so travelers know whether to wait or book now.

  • What is the Hacker Fare option on flights from John Wayne (Santa Ana) to South America?

    Hacker Fares allow you to combine one-way tickets in order to save you money over a traditional round-trip ticket. You could then fly to South America with an airline and back to John Wayne (Santa Ana) with another airline.

  • What is KAYAK's "flexible dates" feature and why should I care when looking for a flight from John Wayne (Santa Ana) to South America?

    Sometimes travel dates aren't set in stone. If your preferred travel dates have some wiggle room, flexible dates will show you all the options when flying to South America from John Wayne (Santa Ana) up to 3 days before/after your preferred dates. You can then pick the flights that suit you best.

See more FAQs

Top tips for finding cheap flights to South America

  • Morning departure is around 4% more expensive than an evening flight, on average*.
*Average of the lowest prices shown in KAYAK’s search results for departures within the next 30 days

Top 4 airlines serving from Santa Ana to South America

Need help choosing which airline to fly with from Santa Ana to South America? KAYAK airline reviews give an overall score for each airline based on loads of factors, including comfort, boarding, in-flight entertainment and more, to make your decision easier. See airline scores according to verified KAYAK customer reviews.
8.0
DeltaOverall score based on 10295 reviews
7.4Food
7.9Comfort
8.2Boarding
8.6Crew
8.0Entertainment
Airline reviews

There was plenty of overhead room but half of the passengers were told they had to check their carryon bags. My partner and I checked in as early as possible and our seats were split across the aisle.

4.0 OkayBrooke, Jun 2024SFO - MSP
Read more about Delta reviews

There was plenty of overhead room but half of the passengers were told they had to check their carryon bags. My partner and I checked in as early as possible and our seats were split across the aisle.

Flew first class so everything was great. But maybe because the flights were red eye, no meals were served, just chips. I flew Alaska Air 1st class at 9PM (2 hour flight) and they served beef short rib sliders!

There was a loud squeaky sound the whole time we were flying.

I didn’t not like that I could not select my seat and ended up with the worse seat.

The landing was bad and the hostess came two times and i was sleeping but when she served the person that nexts to me I woke up and she didn’t even asked me if I need any drink or snacks two times!!!!

Plane was late because of a mechanical malfunction and the food listed as available was not. Flight attendants seem over worked and under paid. They just done seem happy. And that can be seen in their faces.

Waited 3 hours on a plane to de-ice due to manpower issues. Waited another hour and a half once we landed because of a gate issue. Missed my connections. Created. A total of 13 hours of delay.

Great, on time departure, friendly and accommodating crew, great leg room, Smith flight

Plane was turned around due to fog half way into the flight, Delta did not properly direct passengers to stay on same flight and instead failed to properly rebook on Alaska

Honestly, I didn’t expect that I will experience this long time wait during the check in. There was only one person who was taking care of the passengers for the economy class and it took us to wait about one hour to do our check i. As a result we barely get to the airplane as the gate was at the end of the airport. That is totally not professional where one crue is working at the registration desk with economy and 3-4 crues are helping for the business class.

Everything was as you would expect in coach - fine. Flight was close to on time.

It was confusing because I got a notification that my gate was changed when in reality it wasn’t

I missed my plane because there was a lot of people during the migration process. The airline has the chance to care for their clients and they could get the passengers missing in the flight. I lost a day of work and Montfort transportation to go back home and go to the airport again. Unfortunately the airline doesn’t care about that. I use latam at least 4 times a year, so I guess I need to be treat better. In addition, one on my baggages didyarricw to my destination. So frustrated with this trip.

It’s been some time since I saw the plane and the cabin that old and worn out.

No air in the middle rows. Had a hard time breathing. Was dying of heat.

I loved how polite the crew was even though some of them wasn't the best with English that they still done everything they could to help me with my needs food was amazing

Horrific checkin procedure with neither Delta nor Latam figuring out how to check me in. 4 hrs on customer support with both and both airlines pointing to each other who should do checking. I was not checked in until morning of flight, which for international flight is concerning.

It was a good experience, the flight was a little too long & the food was ok

Hostile flight attendants. Second flight with Jose so much better. Arrived 1/2 hour early. Thanks.

Liked check in process To improve: food and beverages. Not second round was offered and meal had no salad.

Why does it have to be painful to fly long distances?

Horrible, the flights kept delaying, so it is obvious that we won't be able to make it to the next connection. No easier/real agent on site to help you figure this out. UA agent on other counters refuse to assist you and direct us to use the QR code/call customer service. So inefficient and poor. While technology seems convenient, but it's not the best interest/experience for customers need help while there is active issue need assistance.

Food is very bad and entertint not too many options ... flight attendet service is not good

Everything was pretty good except for food. They need to improve on it compared to other airlines.

Flight was delayed due to the late arrival of the catering truck, which is quite unacceptable. There was a beverage service, but no pretzel, or cookie, or nuts were served in coach.

I had a great flight. Everything went smoothly and the flight arrived early.

Aisle chair was good and liked the foot bar preventing you from putting your foot in the isle, The breakfast on this international flight to Zurich was horrible (Europeans, specially, used to good food) may make this a dealbreaker for booking with United Airlines again. I agreed with my Spanish fellow passenger.

On time take off…US cabins look tired and need of refresh!

Backpack should NOT allowed put in the flight bin , only put it under the seat. I can't find space put my carry on luggage!!! and I pay for it ! that was very bad experience

I paid $380 for my one-way ticket from California to Minnesota. The fair did not include online check-in. I received instructions from their app to check in at a kiosk. At the kiosk, the boarding pass would not print until an actual person came to verify that I had a personal item and not a carry-on item, On the plane, the person next to me was drunk and allowed to continue to order alcohol. United is garbage I’d rather fly spirit.

The flight was delayed several times without explanation. The seats were terribly uncomfortable and wifi isn’t included. All these make for a less than ideal flight.

Internet service was erratic. Crew service was poor and slow. My luggage on this non-stop flight was lost and not recovered

Flight was 1/2 hour delayed leaving Phoenix. Otherwise it was an average flight. Flight crew on this trip was very nice.

Horrible - they lied to me about baggage & boarding, even though I specifically spoke to their agents the day before my flight about my issue. When I showed up they did not let me board and stranded me at my airport until I bought a new flight with money I did not have to spend.

Not sure why JAL partnered with American Airlines because their service is no where near similar. Flight attendants were not friendly and didn’t smile. Food was horrible…

The experience was great and much better than the flight going out. of course I was in first class but the service was excellent

Comfort of seats, ease of boarding. Food selection could be better

Food options were limited which is absolutely embarrassing for a Flight of this size The staff did not come around as much and I am not accustomed to such poor service from American Airlines Drinks I believe were limited to soda and water

Crew were attentive and friendly. Flight was smooth and early! I enjoyed the less crowded plane. Thank you!

We are gluten free, there were not any available complimentary gluten free options.

Book cheap flights from John Wayne (Santa Ana) to South America

Recent round-trip flight deals

9/4qua
2 stopsSpirit Airlines
18h 26mSNA-MDE
9/10ter
2 stopsSpirit Airlines
22h 46mMDE-SNA
$458
8/31sáb
2 stopsAmerican Airlines
22h 32mSNA-UIO
9/6sex
2 stopsAmerican Airlines
28h 10mUIO-SNA
$486
10/17qui
1 stopLATAM Airlines
14h 30mSNA-BOG
10/28seg
1 stopLATAM Airlines
12h 33mBOG-SNA
$493
9/2seg
1 stopLATAM Airlines
19h 54mSNA-BOG
9/10ter
1 stopLATAM Airlines
22h 08mBOG-SNA
$503
8/31sáb
2 stopsUnited Airlines
27h 55mSNA-UIO
9/5qui
2 stopsUnited Airlines
22h 04mUIO-SNA
$551
8/31sáb
2 stopsUnited Airlines
29h 15mSNA-UIO
9/5qui
1 stopUnited Airlines
19h 54mUIO-SNA
$567
8/24sáb
2 stopsCopa Airlines
44h 46mSNA-LIM
8/28qua
2 stopsCopa Airlines
16h 08mLIM-SNA
$677
9/19qui
1 stopDelta
21h 45mSNA-LIM
9/23seg
1 stopDelta
22h 28mLIM-SNA
$843
8/14qua
1 stopDelta
21h 15mSNA-SCL
9/2seg
1 stopDelta
17h 01mSCL-SNA
$918
8/6ter
2 stopsCopa Airlines
44h 55mSNA-LIM
8/23sex
2 stopsCopa Airlines
16h 08mLIM-SNA
$936

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Recent one-way flight deals

9/30seg
2 stopsSpirit Airlines
17h 30mSNA-BOG
$181
10/4sex
2 stopsSpirit Airlines
17h 30mSNA-BOG
$210
7/7dom
1 stopAmerican Airlines
14h 11mSNA-UIO
$287
7/7dom
2 stopsAmerican Airlines
22h 15mSNA-UIO
$293
8/26seg
1 stopLATAM Airlines
12h 35mSNA-UIO
$314
8/26seg
2 stopsLATAM Airlines
27h 17mSNA-UIO
$320
11/16sáb
2 stopsUnited Airlines
25h 00mSNA-MDE
$494
10/13dom
1 stopUnited Airlines
18h 26mSNA-GRU
$520
7/3qua
1 stopDelta
12h 20mSNA-LIM
$837
7/1seg
2 stopsDelta
19h 50mSNA-EZE
$867

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Last minute flights from Santa Ana to South America

Last minute flight, train and bus deals

6/15sáb
multi-stopSpirit Airlines
15h 51mSNA-MDE
6/25ter
multi-stopSpirit Airlines
21h 15mMDE-SNA
$696
6/14sex
multi-stopSpirit Airlines
28h 11mSNA-MDE
6/21sex
multi-stopSpirit Airlines
21h 44mMDE-SNA
$806
6/14sex
multi-stop
41h 48mSNA-MDE
6/21sex
multi-stop
24h 13mMDE-SNA
$833
6/14sex
multi-stop
12h 40mSNA-MDE
6/21sex
multi-stop
16h 35mMDE-SNA
$892
6/14sex
multi-stopLATAM Airlines
21h 45mSNA-LIM
6/16dom
multi-stopLATAM Airlines
24h 43mLIM-SNA
$1,227
6/14sex
multi-stopLATAM Airlines
32h 45mSNA-LIM
6/16dom
multi-stopLATAM Airlines
24h 43mLIM-SNA
$1,239
6/14sex
multi-stopAmerican Airlines
13h 36mSNA-MDE
6/21sex
multi-stopAmerican Airlines
11h 06mMDE-SNA
$1,371
6/14sex
multi-stopAmerican Airlines
13h 36mSNA-MDE
6/20qui
multi-stopAmerican Airlines
16h 46mMDE-SNA
$1,376
6/15sáb
multi-stopUnited Airlines
16h 00mSNA-EZE
7/14dom
multi-stopUnited Airlines
20h 49mEZE-SNA
$1,884
6/15sáb
multi-stopUnited Airlines
21h 15mSNA-EZE
7/14dom
multi-stopUnited Airlines
25h 29mEZE-SNA
$1,888

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Santa Ana - South America Flights